Veterinary Biochemistry
The Department of Physiology and Biochemistry, Bombay Veterinary College was established in the year 1940, when an advanced diploma course was started.
UG Syllabus
LectureNo. | Topic |
1 & 2 | Scope and importance of biochemistry. Buffer system and pH. Dissociation of and Henderson – Hasselbalch equation |
3 & 4 | Structure of cell membranes and transport across cell membranes. Donnan membrane equilibrium |
Biochemistry of carbohydrates: Biological significance (structure and properties) of: | |
5 | Monosaccharides (ribose, glucose, fructose, galactose, mannose and amino sugars) |
6 | Disaccharides (maltose, isomaltose, lactose, sucrose and cellobiose |
7 | Polysaccharides (starch, dextrins, dextrans, glycogen, cellulose, inulin, chitin) |
8 | Mucopolysaccharides including bacterial cell wall polysaccharides |
Biochemistry of lipids: | |
9 & 10 | Properties (structure) and biological significance of simple, compound and derived lipids and lipoproteins |
11 | Structure and functions of prostaglandins. Chemistry of bile and bile salts |
12 | Amino acids: Classification and structure of neutral basic and acidic amino acids |
13 | Properties of amino acids: amphoteric nature, optical activity and peptide bond formation |
14 | Structure properties, biological significance and chemical reactions of proteins |
Biochemistry of nucleic acids | |
15 | Chemistry of purines and pyrimidines, nucleosides and nucleotides. Biological significance of nucleosides and nucleotides |
16 | Structures and functions of deoxyribonucleic acid (DNA) and a typical ribonucleic acid |
First Year B.V.Sc& A.H.
Semester II: VPB 122 (Veterinary Intermediary Metabolism)
Credit Hours: 2 + 1 = 3
Tentative lecture schedule
LectureNo. | Topic |
1 & 2 | Enzymes: Definition, classification and EC numbering of enzymes. Coenzymes, cofactors &isoenzymes. Enzyme units: International units, katal, turnover number & specific activity. |
3 & 4 | Properties: Protein nature, Enzyme-substrate complex formation, Modern concept of enzyme specificity of enzyme action: substrate specificity, Group specificity, stereo specificity, optical specificity. |
5 | Factors influencing enzyme action: Effects of temperature, pH, concentration of substrate and enzyme; Enzyme inhibition: Competitive, non competitive, uncompetitive and suicidal inhibition allosteric enzymes. |
6 & 7 | Biological Oxidation: Enzymes and coenzyrnes involved in oxidation and reduction viz. Oxidoreductase, Oxidases, oxygenases, dehydrogenases, Hydroperoxidases& cytochromes. |
8 & 9 | Respiratory chain / electron transport chain, oxidative phosphorylation, inhibitors, uncouplers and other factors influencing electron transport chain |
Carbohydrate metabolism along with bioenergetics: | |
10 | Glycolysis |
11 | Kreb’s cycle along with energetics |
12 | Glyoxilate cycle, HIVIP shunt. Gluconeogenesis |
13 | Cori cycle, Glycogenesis, Glycogenolysis |
14 | Hormonal control of carbohydrate metabolism & regulation of blood sugar. |
Lipid metabolism with bioenergetics: | |
15 | Beta oxidation of fatty acid, Ketone body formation |
16 | Biosynthesis of fatty acids. Triacylglycerol metabolism |
17 | Phospholipids & lipoprotein metabolism |
Protein metabolism: | |
18 | Biosynthesis of proteins |
19 | Degradation of protein: deamination, transamination & decarboxylation of amino acids |
20 | Ammonia transport and urea cycle. |
21 & 22 | Nucleic acids: Metabolism of purines and pyrimidines |
23 | DNA & RNA biosynthesis |
24 | Integration of metabolism |
25 | Metabolic functions of macro nutrients |
26 | Metabolic functions of micro nutrients |
Metabolic functions of lipid soluble vitamins: | |
27 | Metabolic functions of Vitamin A & E |
28 | Metabolic functions of Vitamin D & K |
Metabolic functions of water soluble vitamins: | |
29 | Vitamin C |
30 | Thiamine, Riboflavin, Niacin & Pyridoxine, |
31 | Pantothenic acid, Folic acid & Cynocobalamin. |
32 | Use of isotope in metabolic studies. |
Third Year B.V.Sc& A.H.
Semester VI: VPB-321 Animal Biotechnology Credit Hours: 2 + 1 = 3
Tentative lecture schedule
LectureNo. | Topic |
Endocrinology | |
1 | Definitions, basic concepts and scope of animal biotechnology. |
2 & 3 | Recombinant DNA technology: Principles, procedures and applications |
4 & 5 (Micro) | Gene cloning, vectors and expression vectors. New generation vaccines: subunit, recombinant and recombinant vectored vaccines |
6 | Animal tissue culture: Principles, procedure and application |
7 & 8 | Transformation and cell lines: Principles, procedure and application |
9 | Polymerase chain reaction (PCR) and its application in molecular diagnosis. DNA probes, nucleic acid hybridization |
10 & 11 | Transfection, Transgenic animal and biopharming |
12 & 13 | Construction of genomic library and cDNA library |
14 & 15 | DNA sequencing – genome, sequencing and mapping |
16 | Marker assisted selection and gene banking |
17 | Nutritional biotechnology including bioconversion of lignocellulose, genetic manipulation of microbes for improved feed utilization and health |
18 & 19 | Principles of transfer of nucleic acids and proteins (Southern, Northern and Western blotting), DNA fingerprinting and its applications |
20 | Tumour markers and acute phase proteins |
21 | Hybridoma and monoclonal antibodies |
22 | Fermentation process |
23 | Technologies for milk, meat and leather |
24 (Gyn) | Biotechnological application in animal improvements: Embryo biotechniques, in vivo embryo production, Embryo micromanipulation |
25 | In vitro embryo production, Embryo sexing |
26 | Embryo preservation, Embryo cloning |
27 & 28 | Ethics and regulatory issues in biotechnology, IPR, Bioinforrnatics |
Fourth year B.V.Sc& A.H.
Semester VII
VPB-411 (0+1=1)
Veterinary Clinical Biochemistry
This course is conducted in collaboration with other clinical and Para clinical departments like Medicine, Pathology, Parasitology, Microbiology etc.
These courses come under Diagnostic Laboratory Section under TVCC
Semester VII
VCP-411 (0+5=5)
Veterinary Clinical practice
This course is conducted in collaboration with other clinical and Para clinical departments like Medicine, Pathology, Parasitology, Microbiology etc.
Semester VIII
VCP-421 (0+5=5)
Veterinary Clinical practice
This course is conducted in collaboration with other clinical and Para clinical departments like Medicine, Pathology, Parasitology, Microbiology etc.
Fifth year B.V.Sc& A.H.
VCP-511(0+5=5)
Semester IX
Veterinary Clinical practice
Thiscourseis conducted in collaboration with other clinical and Para clinical departments like Medicine, Pathology, Parasitology, Microbiology etc
PG Syllabus
Tentative lecture schedule | ||
| ||
1] Pre-biotic world and chemical evolution. | ||
2-3] Cellular architecture and molecular organization of cell. | ||
4] Metabolic functions of cell. | ||
UNIT II | ||
5] Thermodynamics, | ||
6] Chemical equilibrium and standard state. | ||
7-8] Living cell as steady state and open system obeying laws of thermodynamics. | ||
9] Minimum energy conformation. | ||
10-11] Quantum mechanical calculation. | ||
12] ∆G and ATP. | ||
UNIT III | ||
13] Properties of water. | ||
14] Homeostasis | ||
15] Colloids and determination of size of colloidal particles. | ||
16] Brownian motion, precipitation, mutual precipitation and protective colloids. | ||
17] Dialysis and ultrafiltration | ||
18-19] Donnan’s theory of membrane equilibrium, membrane hydrolysis | ||
20-21] Application of physicochemical laws in living organisms (osmosis, viscosity, surface forces, adsorption, etc.) | ||
22] Bronsted’s theory of Acids and Bases, titratable and actual acidity. | ||
23] Determination of pH, Henderson – Hasselbalch Equation | ||
24] Buffers and factors affecting buffering capacity. | ||
25] Bicarbonate buffer system, Phosphate buffer system, | ||
26] Protein buffer system and Haemoglobin buffer system. | ||
27] Amino acid buffer system, buffer of RBC’s and plasma. | ||
28-29] Chemical basis of oral and parental fluid/electrolyte therapies | ||
30] Bacterial toxigenic diarrhoeas | ||
31] Problem solving – Lecture1 to12. | ||
32] Problem solving – Lecture13 to30. |
Semester I: VBC 602 (Techniques in Biochemistry)
Credit Hours: 0 + 2 = 2
Tentative lecture schedule | ||
| ||
2] Determination of pKa and buffer concentration | ||
3] Calculation of normality. | ||
4] Principle and application of colorimetry and spectrophotometry. | ||
5] Application NMR-X ray crystallography. (Theoritocal back ground). | ||
6] Principle and application of Paper Chromatography. | ||
7] Principle and application of Thin Layer Chromatography. | ||
8] Principles and applications of Column chromatography. | ||
9] Partition chromatography and adsorption co-efficient. | ||
10] Quantitative and qualitative chromatography of amino acids. | ||
11] Quantitative and qualitative chromatography of lipids. | ||
12] Quantitative and qualitative chromatography of sugars. (Theoritocal back ground) | ||
13] Elution following Column chromatography. | ||
14] Gas chromatography. (Theoritocal back ground) | ||
15] Packing of column and choice of detectors and densitometry. | ||
16] Application of electrophoresis. Electrophoresis of proteins. | ||
17] Electrophoresis of nucleic acids. | ||
18] Use of sodium dodecyl sulfate and molecular weight determination. | ||
19] Use of sodium dodecyl sulfate and molecular weight determination. | ||
20] Densitometry procedures and quantitative assays. | ||
21] Immuno-electrophoresis and its applications. | ||
22-23] Preparation of agar/agarose gel for immuno-electrophoresis. | ||
24] Isoelectrofocussing. | ||
25] Isotacophoresis. | ||
26] Molecular sieving and its application in Biochemistry. | ||
27] General properties of dextran, acrylamide, agar and other media used for gel filtration. | ||
28] Ultracentrifugation– its principle and use. | ||
29-30] Preparative analytical and density gradient ultracentrifugation. | ||
31] Fractionation of sub-cellular components. | ||
32] Molecular weight determination using ultracentrifuge. |
Semester I: VBC 603 (Applications of Genomics and Proteomics in Molecular Biology)
Credit Hours: 2 + 0 = 2
Tentative lecture schedule | ||
| ||
1] Nucleotides and nucleic acids. | ||
2] High order structures, cohesions and condensins in chromosome structure. | ||
3] SMC proteins and sequencing. | ||
4] Mutation and evolution. | ||
5] DNA libraries. | ||
6] Bacterial RNA polymerase. | ||
7] RNA interference. | ||
8] DNA replication. | ||
9] RNA synthesis. | ||
10] Control of gene expression. | ||
11] DNA microarrays/chips. | ||
UNIT II | ||
12] PCR and factors affecting it. | ||
13] r-DNA technology in improving domestic animals. | ||
14] RELP, Gene and gene products. | ||
15] Genetic changes in hereditary diseases, cancer and detection using DNA probes. | ||
16] Gene Therapy, DNA vaccines, anti-tumor antibodies. | ||
17] Telomerases and Topoisomerases in treatment of diseases. | ||
18] Staphylococcus resistance to erythromycin. | ||
UNIT III | ||
19] Peptide bonds and protein structure. | ||
20] Acid-base properties and stereochemistry of proteins. | ||
21] Side chain modifications and biological activities of proteins. | ||
22] Green fluorescent protein and use. | ||
23] Polypeptide diversity, protein purification and analysis. | ||
24] Protein sequencing, reconstructing the protein sequence. | ||
25] Gene duplication and protein families. | ||
26] Protein modules, combinatorial peptide libraries folding. | ||
27] Structural bio-informatics. | ||
28] Protein structure prediction, designing and Proteomics. | ||
29] Drug molecules, myoglobin and haemoglobin. | ||
30] Mechanism and co-operativity in Hb. | ||
31] High altitude adaptation in ruminants and equines. | ||
32] Use of amino acid analysis in disease diagnosis. |
Semester I: VBC 604 (Biochemistry of Biomolecules: Carbohydrates Lipids and Membrane’s Structure)
Credit Hours: 2 + 0 = 2
Tentative lecture schedule | ||
| ||
1] Carbohydrates: structure | ||
2] Glycoconjugates in cell surface, extra cellular matrix, | ||
3] Sugar code functions, peptidoglycan-specific antibiotics | ||
4] Cellular effects of Insulin | ||
5] Glucose supply and removal | ||
6] Ruminal fermentation | ||
7] Role of liver | ||
8] Glucose tolerance, indirect monitoring of blood glucose | ||
9] Ketone bodies | ||
UNIT II | ||
10] Lipid classification, | ||
11] Metabolism of LCFA, TAG, PL, | ||
12] Sphingolipids, cholesterol, lipoproteins | ||
13] Regulation of lipid metabolism in fed and fasted states | ||
14] Regulation of FA oxidation, fas as regulatory molecules | ||
15] Glucose production and fas in type II diabetes | ||
16] Ketone bodies as fuel. | ||
UNIT III | ||
17] Lipid bilayers, lipid motility, | ||
18] Integral membrane proteins, lipid linked proteins, peripheral membrane proteins | ||
19] Fluid mosaic model, membrane skeleton, | ||
20] Lipid asymmetry, vesicle trafficking | ||
21] Secretory pathway, membrane rafts | ||
22] Caveolae fusion | ||
23] Lung surfactant | ||
24] Structure of bacterial rhodopsin | ||
25] Thermodynamics of membrane transport | ||
26] Ionophores, porins, ion channels, aquaporins, transport proteins | ||
27] P and F types (Na+ – K+ ) atpases | ||
28] Ca , Ion–gradient, Gap Junction, | ||
29] Cl–HCO- exchanger | ||
30] Cardiac 2+3 glycosides | ||
31] Abnormalities in cell membrane fluidity | ||
32] Haemolyticanaemia |
Semester I: VBC 604 (Biochemistry of Biomolecules: Carbohydrates Lipids and Membrane’s Structure)
Credit Hours: 2 + 0 = 2
Tentative lecture schedule | ||
| ||
1] Carbohydrates: structure | ||
2] Glycoconjugates in cell surface, extra cellular matrix, | ||
3] Sugar code functions, peptidoglycan-specific antibiotics | ||
4] Cellular effects of Insulin | ||
5] Glucose supply and removal | ||
6] Ruminal fermentation | ||
7] Role of liver | ||
8] Glucose tolerance, indirect monitoring of blood glucose | ||
9] Ketone bodies | ||
UNIT II | ||
10] Lipid classification, | ||
11] Metabolism of LCFA, TAG, PL, | ||
12] Sphingolipids, cholesterol, lipoproteins | ||
13] Regulation of lipid metabolism in fed and fasted states | ||
14] Regulation of FA oxidation, fas as regulatory molecules | ||
15] Glucose production and fas in type II diabetes | ||
16] Ketone bodies as fuel. | ||
UNIT III | ||
17] Lipid bilayers, lipid motility, | ||
18] Integral membrane proteins, lipid linked proteins, peripheral membrane proteins | ||
19] Fluid mosaic model, membrane skeleton, | ||
20] Lipid asymmetry, vesicle trafficking | ||
21] Secretory pathway, membrane rafts | ||
22] Caveolae fusion | ||
23] Lung surfactant | ||
24] Structure of bacterial rhodopsin | ||
25] Thermodynamics of membrane transport | ||
26] Ionophores, porins, ion channels, aquaporins, transport proteins | ||
27] P and F types (Na+ – K+ ) atpases | ||
28] Ca , Ion–gradient, Gap Junction, | ||
29] Cl–HCO- exchanger | ||
30] Cardiac 2+3 glycosides | ||
31] Abnormalities in cell membrane fluidity | ||
32] Haemolyticanaemia |
Semester I: VBC 605 (Enzyme Catalysis, Kinetics, Inhibition and Regulation)
Credit Hours: 2 + 0 = 2
Tentative lecture schedule | ||
| ||
1] Introduction to the enzymes their classification and functions. | ||
2] Enzyme activation energy. | ||
3] Mechanisms of acid-base reaction co-ordination. | ||
4] Mechanisms of covalent reaction co-ordination. | ||
5] Mechanisms of metal ion reaction co-ordination. | ||
6] Proximity and orientation effects. | ||
7] Preferential transitional state binding. | ||
UNIT II | ||
8] Chemical kinetics of reaction. | ||
9] Enzyme kinetics of reaction. | ||
10] Kinetic data analysis. | ||
11] Bisubstrate reactions. | ||
12-13] Competitive, Uncompetitive, Mixed inhibitors. | ||
14] Allosteric regulation. | ||
15] Enzymes in drug designing. | ||
16] Enzymes in drug discovery. | ||
17] Bioavailability and toxicity. | ||
18] Enzymes in clinical trials. | ||
19] Cytochrome P450 and adverse drug reactions. | ||
20] Synthesis of bacterial peptidoglycans. | ||
21] Synthesis of Oxygenases. | ||
22] Synthesis of mixed function oxidases. | ||
23] Enzyme linked diagnostics. | ||
UNIT III | ||
24] Lysozymes. | ||
25] Serine proteases. | ||
26] Physiology and tumor cell metastasis. | ||
27] Nerve poisons. | ||
28] Blood coagulation cascade. | ||
29] Equine immuno-deficiency enzyme inhibitors. | ||
30] Suicide activators (DFMO for inhibition of ornithine decarboxylases in trypanosomiasis). | ||
31] Problem solving – Lecture1 to12. | ||
32] Problem solving – Lecture13 to30. |
Semester II: VBC 606 (Metabolism – I: Carbohydrates and Lipids)
Credit Hours: 2 + 0 = 2
Tentative lecture schedule | ||
| ||
1] Metabolic control, | ||
2] Analyses for enzymes limiting the flux through a pathway. | ||
3] Trophic strategies, | ||
4] Universal mapping of metabolic pathways | ||
5] Thermodynamic relationships. G, | ||
6] ATP and phosphoryl group transfer | ||
7] Coupled reactions, thioesters, | ||
8] NAD+ and FAD. | ||
UNIT II | ||
9] Overview of carbohydrate and lipid cycles, | ||
10] Control of glycolysis | ||
11] Glycolysis in cancer cells | ||
12] Control of pentose phosphate pathways | ||
13] Deficiency of glucose-6-phosphate dehydrogenase | ||
14] Control of glycogen metabolism | ||
15] Control of gluconeogenesis | ||
16] GSD. | ||
17] Regulation of citric acid cycle | ||
18] Pathways that use citric acid intermediates | ||
19] Sugar interconversions and nucleotide – linked sugar formation | ||
20] Disorders associated with impairment of metabolism | ||
UNIT III | ||
21] Electron transport and oxidative phosphorylation | ||
22] Generation of heat by uncoupling in brown adipose tissue. | ||
UNIT IV | ||
23] Regulation of fatty acid metabolism | ||
24] Inhibitors of fatty acids biosynthesis | ||
25] Sphingolipid degradation | ||
26] Lipid storage disease | ||
27] Regulation of cholesterol synthesis | ||
28] PGs in NSAID | ||
29] Leukotrienes | ||
30] HETEs | ||
31] Hypersensitivity | ||
32] Influence of glucose metabolism on lipid metabolism |
Semester II: VBC 607 (Metabolism – II: Nucleic Acids and Amino Acids)
Credit Hours: 2 + 0 = 2
Tentative lecture schedule | ||
| ||
1] Overview of pathways of amino acid | ||
2] Overview of pathways of nucleic acid metabolism | ||
3] Lysosomal degradation | ||
4] Ubiquitin | ||
5] Proteosome | ||
6] Breakdown of amino acids | ||
7] Heme biosynthesis and degradation | ||
8] Biosynthesis of physiologically active amines | ||
9] Nitric oxide | ||
10] Homocystein as marker of disease | ||
11-12] Diseases of amino acid metabolism | ||
13] Porphyrias | ||
UNIT II | ||
14] Nucleotide synthesis and degradation | ||
15] Inhibition of thymidylate synthesis in cancer therapy | ||
16] Mutation in coenzyme binding sites and diseases | ||
17] Forces stabilizing NA structure | ||
18] Restriction endonucleases | ||
19] Small inhibitory RNAs | ||
20] Chromatin organization | ||
21] Inhibitors of topoisomerases as antibiotic | ||
22] Anti-cancer agents interfering with purine and pyramidine metabolism | ||
UNIT III | ||
23] Viral nucleic acids | ||
24] DNA damage and repair | ||
25] Telomerase | ||
26] Ageing and cancer | ||
27] Topoisomerases as drug targets | ||
28] Chemotherapy can target precursors of DNA synthesis | ||
29] Antibiotics and toxins that target RNA polymerase | ||
30] Lysosomal enzymes | ||
31] Gout | ||
32] Diseases in purine and pyrimidine nucleotide metabolic impairment |
Semester II: VBC 608 (Metabolism – III: Integration and Regulation)
Credit Hours: 2 + 0 = 2
Tentative lecture schedule | |||
| |||
1] Regulation of carbohydrate metabolism | |||
2] Regulation of lipid metabolism | |||
3] Regulation of protein metabolism | |||
4] Regulation of nucleic acid metabolism | |||
5] Integration all metabolic pathways | |||
UNIT II | |||
6] Organ specialization in fuel metabolism: Brain, muscle | |||
7] Organ specialization in fuel metabolism: adipose tissue, liver, kidney | |||
8] Inter organ metabolic pathways | |||
9] Hormonal control of fuel metabolism | |||
10] Tracing metabolic fates perturbing the system | |||
UNIT III | |||
11] Signal transduction, gated ion channels | |||
12] G-proteins | |||
13] Adenylatecyclase, cGMP, Ca2+ | |||
14] Receptor tyrosine kinase | |||
15] Protein phosphatases | |||
16] Interaction of Ca2+ with phosphoserine/tyrosine | |||
17] Integrations of proteins/ messengers in signal transduction | |||
18] Drugs and toxins | |||
19] Cell cycle and CDKs that affect cell signaling | |||
UNIT IV | |||
20] Oncogenes and cancers | |||
21] Mitochondrial genes and diseases | |||
22] Reactive oxygen species | |||
23] Cyanide and arsenic poisoning | |||
24] Metabolic inter-relationships in obesity, diabetes, and cancer | |||
25] Metabolic inter-relationships in aerobic and anaerobic exercise in horses | |||
26] Metabolic inter-relationships in pregnancy, lactation and stress injury | |||
27] Mitochondria in apoptosis and oxidative stress, cell suicide | |||
28] Liver diseases | |||
29] Renal diseases | |||
30] Acid-base balance | |||
31] Metabolic/sensory transduction in nervous tissue | |||
32] | Vision, blood coagulation |
Semester II: VBC 609 (Central Dogma and Protein)
Credit Hours: 2 + 0 = 2
Tentative lecture schedule | ||
| ||
1] Overview of transcription and translation in eukaryotes | ||
2] Collision between DNA polymerase and RNA polymerase | ||
3] Inhibitors of transcription | ||
4] Introns | ||
5] Evolution and expansion of the genetic code | ||
UNIT II | ||
6] The effects of antibiotics and toxins on protein synthesis | ||
7] X – chromosome inactivation | ||
8] Eukaryotic gene expression | ||
9] Protein targeting | ||
UNIT III | ||
10] Actin structure | ||
11] Microfilament dynamics | ||
12] Actin-myosin reacting cycle | ||
13] Tubulin dimmer | ||
14] Microtubules dynamics | ||
15] Kinensins and dyeins | ||
UNIT IV | ||
16] Antigen-antibody binding | ||
17] Cytokines | ||
18] Principles of immunochemical methods | ||
19] Agglutination, precipitation | ||
20] Typing of major histo-compatibility antigens | ||
21] Blood group substances in farm animals | ||
UNIT V | ||
22] Proteins as infectious agents (prions – BSE). | ||
23] Protein misfolding and aggregation | ||
24] Plasma proteins, synthesis, functions | ||
25] Influences of physiological factors and inflammation on proteins | ||
26] Dysproteinemias | ||
27] Defects in collagen synthesis | ||
28] Transmissible multiple drug resistance | ||
29] Transcription factors and cardiovascular diseases | ||
30] Transferrin | ||
31] Lactoferrin | ||
32] Ferritin and Ceruloplasmin |
Semester II: VBC 610 (Clinical Biochemistry of Animals)
Credit Hours: 2 + 1 = 3
Tentative lecture schedule | ||
| ||
1-3] Disturbances of gastro-intestinal function- Irritable Bowel Syndrone Ulcerative Collitis | ||
4-6] Disturbances of rumen function. – Bloat (Tympany), urea poisoning, acute rumen indigestion, Lactic acidosis | ||
7-8] Pickled pigs and malignant hyperthermia. | ||
9-10] Diagnosis of neuromuscular disorders. Eg. mitochondrialdiseases | ||
UNIT II | ||
11] Myocardial infarction, | ||
12] Respiratory distress syndrome. | ||
13-14] Primary renal dysfunctions and test, | ||
15-16] Doping. Problems in game horses. | ||
UNIT III | ||
17-18] Enzymes of diagnostic importance. | ||
19-20] Toxicity of ammonia in animals.Genetic defects in urea cycle. | ||
21] Lysosomal storage diseases. | ||
22-23] ATP synthase inhibitory protein during ischemia. Ischaemic – reperfusion injury. | ||
UNIT IV | ||
24-25] Molecular oncology and tumor markers. | ||
26] CSF characteristics in diseases. | ||
27] Clinical Biochemistry in toxicology. | ||
28] Glycosylated hemoglobin, HbA1c, fructosamine. | ||
29] Deranged glucose metabolism in cancerous tissue. | ||
30] Free Radical damage. | ||
31] Problem solving for lectures 1-16 | ||
32] Problem solving for lectures 17-30 |
Semester III: VBC 606 (Biochemical Basis of Diseases of Domestic Animals)
Credit Hours: 2 + 0 = 2Tentative lecture schedule | ||
| ||
1] Diabetes mellitus | ||
2-3] Hyperinsulemia, galactosemia, hypoglycaemia of baby pigs, | ||
4] Glycogen Storage Disease. | ||
5] Carbohydrate balance in ruminants. | ||
6] Biochemical alterations in body fluids of ruminants in hypoglycaemia, | ||
7] Ruminant ketosis. | ||
UNIT II | ||
8] Hypercholesterolemia, | ||
9] Atherosclerosis, | ||
10-11] hyperlipidemia in canine, feline, equine. | ||
12] Pathophysiology of ketonemia. | ||
13-14] Ketosis associated with fasting, diabetes, pregnancy, lactation and post exercise. | ||
UNIT III | ||
15] Anemias of the newborn, | ||
16-17] Cytosolic enzyme deficiencies and membrane abnormalities in erythrocytes. | ||
18] Porphyrins and porphyrias. | ||
19] Disorders of iron metabolism, | ||
21] Neutrophil function defects and its testing. | ||
22] Equine immuno-deficiency. | ||
UNIT IV | ||
23-24] Hepatic insufficiencies and its laboratory assessment | ||
25-26] Pancreatitis and insuffiency | ||
27-28] Metabolic diseases of Ca, P, Mg metabolism | ||
29] Iron overload and injection | ||
30] Inorganic polyphosphate metabolism | ||
31] Problem solving for lectures 1 – 16 | ||
32] Problem solving for lectures 17 – 30 |
Semester III: VBC 612 (Endocrinology and Reproductive Biochemistry)
Credit Hours: 2 + 0 = 2
Tentative lecture schedule | ||
| ||
1-2] Mechanism of hormone action | ||
3] Receptor binding, | ||
4-6] Biosynthesis of hormones and factors | ||
7-8] Metabolic aspects in physio-pathology of hormones, factors, and minerals. | ||
UNIT II | ||
9-10] Metabolic functions of the hormones of the hypothalamus | ||
11-12] Metabolic functions of pituitary | ||
13] Metabolic functions of Thyroid | ||
14] Metabolic functions of parathyroid | ||
15] Metabolic functions of pancreas | ||
16-17] Metabolic functions of adrenal | ||
18] Metabolic functions of pineal | ||
19] Metabolic functions of ovaries | ||
20] Metabolic functions of testes | ||
21-22] Biochemistry of prostaglandins and related agents. | ||
23-24] Clinical endocrine aspects in production in domestic animals | ||
25-26] Clinical endocrine aspects in reproduction status in domestic animals | ||
27-28] Clinical endocrine aspects in production in poultry | ||
29-30] Clinical endocrine aspects in reproduction status in poultry | ||
31] Problem solving for lectures 1-15 | ||
32] Problem solving for lectures 15-30 |
Semester III: VBC 613 (Biochemical Basis of Animal Production)
Credit Hours: 2 + 1 = 3
Tentative lecture schedule | ||
| ||
1-2] Chemistry of milk lipids, | ||
3-4] Chemistry of milk proteins, | ||
5-6] Chemistry of milk carbohydrates, | ||
7-8] Chemistry of milk minerals, | ||
9-10] Chemistry of milk vitamins, | ||
11-12] Chemistry of milk pigments and enzymes. | ||
13-14] Structure of milk lipids, fat globular membranes, modification of milk fat. | ||
15-16] Milk proteins – casein, amino acid composition, whey proteins, immunoglobulins, genetic polymorphism. | ||
17-18] Carbohydrates: structure and sweetness. | ||
UNIT II | ||
19-20] The biochemistry controlling postmortem energy metabolism mechanisms. | ||
21-22] Application of genomic technologies to the improvement of meat quality of farm animals. | ||
23-24] Identification of meat quality parameters by proteomics. | ||
25-26] Application of proteomics to understand the molecular mechanisms behind meat quality. | ||
27-28] Oxidative stability of post mortem muscles from sheep of various ages. | ||
UNIT III | ||
29-30] Metabolic demands of draft animals, and biochemical aspects of work and kinesiology. | ||
31] Problem solving for lectures 1-15 | ||
32] Problem solving for lectures 15-30 | ||
List of Research Topics of M.V.Sc Theses
List of Research Topics of M.V.Sc Theses
Sr. No. | Name of the Student | Title of the Thesis | Year | University |
1. | Dr. V. G. Joshi | Some haematological observations on Rathi cows | 1968 | Bombay |
2. | Dr. Y. G. Gadgil | Studies on blood serum proteins of Rathi cows | 1968 | Bombay |
3. | Dr. (Mrs.) B. A. Talvelkar | Studies on certain aspects of eggs in the pure bred strains of White Leghorn, Australorp and their cross White Austro | 1970 | MPKV |
4. | Dr. K. B. Puranik | Studies on blood serum proteins of crossbred cow calves and Murrah buffalo calves by starch agar gel electrophoresis | 1970 | MPKV |
5. | Dr. G. D. Behre | Studies on blood serum proteins of chickens of exotic breeds and of local (Desi) chickens. | 1970 | MPKV |
6. | Dr. M. V. Chavan | Studies on the use of biostimulator (spleen extract) in broilers | 1975 | KKV |
7. | Dr. S. J. Pardikar | Haematological and biochemical studies in sheep and goats | 1976 | KKV |
8. | Dr. U. K. Parchure | Studies on serum proteins in Bannur sheep | 1978 | KKV |
9. | Dr. M. Rafi | Studies on some serum electrolyte levels in Bannur sheep | 1986 | KKV |
10. | Dr. (Ms.) A. J. Mhatre | Studies on some haematological and biochemical parameters in broilers under different temperature regimes. | 1986 | KKV |
11. | Dr. P. B. Bhangale | A study on effects of some climatic factors on physiological responses in Gir and crossbred lactating cows | 1986 | KKV |
12. | Dr. M. D. Patil | Studies on haematology of Murrah buffaloes | 1989 | KKV |
13. | Dr. Mir Manzoor | Concentration of some major elements in blood plasma and milk of crossbred lactating cows during different stages of lactation | 1990 | KKV |
14. | Dr. S. D. Dhande | Immunoglobulin levels in lacteal secretions of indigenous and crossbred cows in early lactation | 1992 | KKV |
15. | Dr. S. W. Bonde | Passive immune status in neonatal crossbred calves | 1992 | KKV |
16. | Dr. B. V. Jichkar | Serum immunoglobulin levels in crossbred cows | 1992 | KKV |
17. | Dr. D. S. Jagdale | Studies on estradiol – 17ß, progesterone and lipid profile in crossbred cows | 1993 | KKV |
18. | Dr. S. H. Dalvi | Blood serum thyroid hormone concentration during late pregnancy, parturition and early lactation of crossbred cows | 1993 | KKV |
19. | Dr. S. M. Deshpande | Studies on macro elements during gestation and early postpartum period in Gir and crossbred cows | 1994 | KKV |
20. | Dr. P. D. Bansode | Effect of oxytocin on milk production and its composition in crossbred cows | 1994 | KKV |
21. | Dr. N. S. Sonawane | Effect of bovine somatotropin on blood lipid profile in lactating crossbred cows. | 1995 | KKV |
22. | Dr. S. K. Bhere | Effect of administration of bovine somatotropin on milk yield, milk composition, feed intake and body weights of lactating crossbred cows | 1996 | KKV |
23. | Dr. V. D. Garje | Effect of exogenous bovine somatotropin on major elements of milk in lactating crossbred cows | 1996 | KKV |
24. | Dr. L. R. Gadhave | Studies on serum protein profile during gestation and early postpartum period in Gir and crossbred cows | 1997 | KKV |
25. | Dr. S. D. Ingole | Serum enzyme profile during gestation and early lactation in Gir and crossbred cows | 1997 | KKV |
26. | Dr. (Ms.) S. V. Bharucha | Effect of bovine somatotropin on blood serum proteins in lactating crossbred cows | 1997 | KKV |
27. | Dr. B. V. Atak | Serum enzyme profile during growth in Gir and crossbred calves | 1998 | KKV |
28. | Dr. S. P. Patil | Studies on serum protein profile during growth in Gir and crossbred calves | 1998 | KKV |
29. | Dr. (Ms.) S. V. Bhide | Effect of induced hypothyroidism on blood biochemical constituents in goats | 1998 | KKV |
30. | Dr. N. B. Vadnere | Effect of induced hypothyroidism on haematology and thyroid hormones concentration in goats | 1998 | KKV |
31. | Dr. M. N. Harlikar | Trace element profile during growth in crossbred calves and heifers | 1999 | KKV |
32. | Dr. (Ms.) A. S. Lourenco | Haematological profile in crossbred calves and heifers | 1999 | KKV |
33 | Dr. R. R. Patil | Trace element profile during gestation and lactation in crossbred cows | 2000 | KKV |
34 | Dr. Y. S. Mehere | Haematological and trace element profile during peripartum period in crossbred cows | 2000 | KKV |
35 | Dr. (Ms.) A. A. Pimputkar | Haematological profile during gestation and lactation in crossbred cows | 2000 | KKV |
36 | Dr. K. B. Bahiram | Mineral profile during growth in crossbred calves and heifers | 2001 | BSKKV |
37 | Dr. D. N. Paikrao | Mineral profile during gestation, peripartum period and lactation in crossbred cows | 2001 | BSKKV |
38 | Dr. R. R. Dhotre | Comparative study of serum testosterone profile and seminal characteristics of cow and buffalo bulls | 2001 | BSKKV |
39 | Dr. S. B. Nalavade | Comparative study of serum lipid profile in buffalo bulls and cow bulls | 2002 | MAFSU |
40 | Dr. P. L. Gade | Serum trace elements profile in cow bull and buffalo bull | 2002 | MAFSU |
41 | Dr. S. Y. Bidye | Concentrations of serum thyroxine, triiodothyronine and thyroid stimulating hormone in buffalo and cow bulls | 2002 | MAFSU |
42 | Dr. T. P. Bawane | Serum Inhibin, FSH, LH concentrations and seminal plasma Inhibin activity in buffalo and cow bulls | 2003 | MAFSU |
43 | Dr. (Ms.) G. V. Parab | Comparative study of serum protein profile in buffalo bulls and cow bulls | 2003 | MAFSU |
44 | Dr. S. R. Nikam | Seminal plasma lipid profile in buffalo and cow bulls | 2003 | MAFSU |
45 | Dr. S. B. Kancharla | Seminal plasma trace element profile in buffalo and cow bulls | 2003 | MAFSU |
46 | Dr. (Ms.) S. D. Borkar | Effect of inhibin immunization on seminal characteristics in buffalo bulls | 2004 | MAFSU |
47 | Dr. S. N. Itankar | Effect of Inhibin immunization on haematological parameters in buffalo bulls | 2004 | MAFSU |
48 | Dr. S. K. Aghadate | Effect of Inhibin immunization on serum electrolytes concentration in buffalo bulls | 2005 | MAFSU |
49 | Dr. D. V. Ingavale | Effect of Inhibin immunization on serum thyroxine, triiodothyronine and thyroid stimulating hormone in buffalo bulls | 2005 | MAFSU |
50 | Dr. (Ms.) S.D. Konkar | Effect of inhibinimmunisation on serum protien profile in buffalo bulls | 2005 | MAFSU |
51 | Dr. (Ms.) S. D. Dhaware | Follicular fluid biochemical profile of buffalo | 2006 | MAFSU |
52 | Dr. (Ms.) Shiny Joy | Follicular fluid protein profile in buffalo | 2006 | MAFSU |
53 | Dr. (Ms) V. K. More | Electrolyte concentration in follicular fluid of sheep | 2006 | MAFSU |
54 | Dr. (Ms.) A. D. Gandhe | Serum Protein profile during lactation in buffalo | 2007 | MAFSU |
55 | Dr. P. M Tripathi | Serum lipid profile during lactation in buffalo | 2007 | MAFSU |
56 | Dr. (Ms.) V. M. Tekade | Serum Protein profile during early pregnancy in buffaloes | 2009 | MAFSU |
57 | Dr. SushantaDebbarma | Serum progesterone and thyroid hormone profile during gestation and early post partum period in goats | 2010 | MAFSU |
58 | Dr. T. R. Mahanwar | Serum enzyme profile during gestation and early post partum period in goats | 2010 |
List of Research Topics of Ph.D. Theses
List of Research Topics of Ph.D. Theses
Sr. | ||||
Sr. No. | Name of the Student | Title of the Thesis | Year | University |
1. | Dr. B. A. Kulkarni | Studies on Immunoglobulins in Indian Buffaloes (Bosbubalusbubalis) | 1971 | Bombay |
2. | Dr. (Mrs.) A. M. Mantri | Studies on the Leutinizing Hormone (LH) in Domestic Fowl (Gallus Domesticus) | 1977 | KKV |
3. | Dr. V. G. Joshi | Study of Thyroid Function in Different Strains of Fowl in Relation to Growth Rate and Laying Performance | 1978 | KKV |
4. | Dr. (Mrs.) B. A. Talvelkar | Studies on Serum Leutinizing Hormone and Prolactin Levels in Purebred Gir and Crossbred Dairy Animals | 1980 | KKV |
5 | Dr. B. T. Deshmukh | Influence of Frequency of Feeding and Milking on the Secretion of Milk in Lactating Crossbred Cows | 1985 | Kurukshetra |
7 | Dr. (Mrs.) A. S. Nagvekar | Profiles of serum Somatotropin, Gonadotropin, Ovarian Steriods and Thyroidal Hormones during gestation of Buffalo | 2009 | MAFSU |