Overview

Veterinary Pharmacology and Toxicology

Department of Pharmacology and Toxicology was established in 1961. Post-graduate study programme started in the year 1972. Ph. D. degree programme partly by papers and partly by research has been instituted from the year 2004. So far 83 candidates completed M.V.Sc. successfully and two have completed Ph.D. by research.

UG Syllabus

VPT 311

SEMESTER- V

Title:

THEORY

Historical development branches and scope of Pharmacology. Sources and nature of drugs. Pharmacological terms and definitions. Principles of drug activity: Pharmacokinetics – Routes of drug administration, absorption, distribution, biotransformation and excretion of drugs. Pharmacodynamics-Concept of drug and receptor, dose-response relationship, terms related to drug activity and factors modifying the drug effect and dosage. Fundamentals of drug-screening and assay of drugs. Adverse drug reactions, drug interaction, drug- designing and development, bio prospecting of drugs. Introduction to biopharmaceutics and gene therapy.

Drugs acting on digestive system: Stomachics, antacids and antiulcers, prokinetics, carminatives, antizymotics, emetics, antiemetics, purgatives, antidiarrhoeals, cholerectics and cholagogues. Rumen pharmacology. Drugs acting on Cardiovascular system: cardiac glycosides, antiarrhythmic drugs, vasodilators and antihypertensive agents, haematjnics, coagulants and anticoagulants. Drugs acting on respiratory system: Expectorants and antitussives, respiratory stimulants, bronchodilators and mucolytics. Drugs acting on urogenital system: Diuretics, urinary alkalizers, and acidifiers, fluid therapy, ecbolics and tocolytics. Pharmacotherapeutics of hormones and vitamins. Drugs acting on skin and mucous membranes: Emollients, demulcents and counter irritants. Bio-enhancers, Immunostimulants and immunosuppressants. New drugs and drug formulations.

PRACTICAL

Pharmacy appliances. Principles of compounding and dispensing. Metrology: systems of weights and measures, pharmacy calculations. Pharmaceutical processes. Pharmaceutical dosage forms Prescription writing, incompatibilities. Drug standards and regulations, Custody of poisons. Compounding and dispensing of powders, ointments, mixtures, liniments, lotions, liquors, tinctures, emulsions, and electuaries.

VPT 321

SEMESTER- VI

VETERINARY NEUROPHARMACOLOGY

VPT-321 Credit Hours 2+1=3

THEORY

Drugs acting on autonomic nervous system: Neurohumoral transmission, adrenoceptors agonists and antagonists, adrenergic- neuron blockers, cholinoceptors agonists and antagonists, ganglionic stimulants and blockers.

Autacoids: Histamine and antihistamine agents, 5-Hydroxytryptamine and its antagonists, prostaglandins, angiotensin and bradykinin.

Drugs acting on central nervous system (CNS): Pharmacology of neurotransmitters History of general anaesthetics and theories of anaesthesia. Inhalent, intravenous and dissociative anaesthetics; hypnotics and sedatives; tranquilizers, psychotropic drugs, anticonvulsants, opioid analgesic, nonsteroidal anti-inflammatory drugs, analeptics and other CNS stimulants, central muscle relaxants.

Drugs acting on somatic nervous system: Local anaesthetics and peripheral muscle relaxants. New drugs end drug formulations.

PRACTICAL

Demonstration of the effect of CNS depressants, analgesics, CNS stimulants, muscle relaxants, anticonvulsants, local anaesthetics in laboratory animals.

Demonstration of the action of adrenergic and cholinergic agonists and antagonists on isolated and intact preparations of the animals

Alternate use of animals as model for demonstration

VPT 411

SEMESTER- VII

VETERINARY CHEMOTHERAPY

VPT-411 Credit Hours 2+0=2

THEORY

Antibacterial agents: Classification, general principles in antibacterial chemotherapy, antibacterial resistance. Sulphonamides and their combination with diaminopyrimidines, sulfones, nitrofurans, nalidixic acid and fluoroquinolones.

Antibiotics: Penicillins and cephalopsorins, aminoglycosides, tetracyclines, chloramphenicol, macrolides, polypeptides. Miscellaneous agents: methenamine, bacitracin. Rifampin. novobiocin, viginamycin, lincosamides and vancomycin.

Antifungal agents: Topical and systemic agents including anti-fungal antibiotics. Anthelmintics: Drugs used against cestodes, trematodes, nematodes, drug resistance, broad-spectrum anthelmintics. Antiprotozoal agents: Drugs used in trypanosomosis, theileriosis, babesiosis, coccidiosis, amoebiosis, giardiosis and trichomonosis. Ectoparasiticides, Antiviral and anticancer agents. Antiseptics and disinfectants. Growth promoters. Common indigenous drugs of plant origin with proven pharmacological and therapeutic efficacies in various animal ailments. New drugs and drug formulations.

VPT 421

VETERINARY TOXICOLOGY

VPT-421 Credit Hours 2+0=2

THEORY

General Toxicology: Definitions, fundamentals and scope of toxicology. Sources and mode of action of poisons. Factors modifying toxicity. General approaches to diagnosis and treatment of poisoning. Toxicity caused by metal and non-metals: Arsenic, lead, mercury, copper, selenium, molybdenum, phosphorus, nitrates and nitrites, common salt and fluoride. Toxicity caused by plants and weeds: Cyanogenetic plants, abrus, lantana, ipomoea, nerium, datura, nux vomica, castor, selenium containing plants oxalate producing plants, plants causing thiamine deficiency. . Drug toxicity and toxicity caused by agrochemicals: organophosphates, carbamates, chlorinated hydrocarbons, pyrethroids. herbicides, fungicides, rodenticides and urea. Residue toxicology: Hazards of residues, concepts of withdrawal time and MRLs, minimizing drug and toxic residues in animal products. Venomous bites and stings: Snake bite, scorpion, spider, wasp stings and toad poisoning. Radiation hazards and industrial toxicants. Toxicity caused by food additives and preservatives.

PG Syllabus

PG syllabus:

VETERINARY PHARMACOLOGY AND TOXICOLOGY

Course Contents

VPT 601 GENERAL PHARMACOLOGY 2+0

Objective

To study the scope of pharmacology and to understand the basic

mechanisms of drug actions and its effects.

Theory

UNIT I History and scope of pharmacology, Principles of drug absorption, distribution, metabolism and elimination. Drug bioavailability and routes of administration.

UNIT II Important pharmacokinetic parameters and their clinical significance.

UNIT III Pharmacodynamics: mechanism of action and the relationship between drug concentration and effect; signal transduction mechanism and drug receptors for physiological regulatory molecules.

UNIT IV Quantitation of drug-receptor interactions and elicited effects. Competitive and non-competitive antagonism. Factors affecting drug response. Adverse drug reactions.

VPT 602 AUTONOMIC AND AUTACOID PHARMACOLOGY 2+1

Objective

To study the pharmacodynamics of autonomic drugs.

Theory

UNIT I: Anatomical and physiological considerations of autonomic nervous system (ANS).

UNIT II: Neurohumoral transmission in ANS.

UNIT III: Pharmacology of cholinergic agonists and antagonists.

UNIT IV: Pharmacology of adrenergic agonists and antagonists.

UNIT V: Ganglionic stimulants and blockers.

UNIT VI: Autacoids: Histamine, serotonin, kinins, eicosanoids and platelet activating factor.

Practical

Pharmacological experiments on intact and isolated preparations for studying the effects of various prototype drugs on vascular, intestinal, respiratory, urinary and reproductive smooth muscles, autonomic ganglia, skeletal muscles; blood pressure, ECG, heart etc.

VPT 603 CNS PHARMACOLOGY 2+1

Objective

To study the pharmacodynamics of drugs acting on CNS.

Theory

UNIT I: Anatomical and physiological considerations of central nervous system (CNS); neurohumoral transmission in CNS.

UNIT II: Historical development, theories, principles and stages of general anaesthesia.

UNIT III: Pharmacology of anaesthetics, sedatives, hypnotics, neuroleptics, antiepileptics.

UNIT IV: CNS stimulants, analeptics, opioid agonists and antagonists; non-steroidal anti-inflammatory agents, central and peripheral muscle relaxants, local anaesthetics, therapeutic gases. euthanizing agents. Doping.

Practical

Study of pharmacodynamics of prototype drugs of each group in experimental animals.

VPT 604 DIGESTIVE AND RESPIRATORY PHARMACOLOGY 2+0

Objective

To study the pharmacological aspects of drugs acting on digestive and

respiratory systems.

Theory

UNIT I: Pharmacology of drugs acting on gastrointestinal tract. Appetite stimulants,

emetics and anti-emetics.

UNIT II: Anti-ulcer drugs, modulators of gastric and intestinal motility and secretions.

UNIT III: Gastrointestinal protectants and adsorbents, laxatives and cathartics.

UNIT IV: Agents promoting digestive functions; bile acids and pancreatic enzymes, drugs affecting liver; rumen pharmacology.

UNIT V: Pharmacology of drugs acting on respiratory system: pathogenesis of inflammatory respiratory diseases.

UNIT VI: Bronchodilators, antitussives, mucolytics, expectorants, decongestants.

UNIT VII: Drugs used in treatment of asthma.

VPT 605 CARDIOVASCULAR AND RENAL PHARMACOLOGY 2+0

Objective

To study the pharmacological aspects of drugs acting on CVS and kidneys.

Theory

UNIT I: Pharmacology of cardiac glycosides.

UNIT II: Antiarrhythmic, antihypertensive and antihyperlipidaemic drugs.

UNIT III: Drugs affecting vasomotor and cardiorespiratory reflex mechanisms and

haemopoietic system.

UNIT IV: Coagulants and anticoagulants, thrombolytic agents.

UNIT V: Pharmacology of drugs affecting renal functions and fluid-electrolyte balance.

UNIT VI: Fluid and electrolyte therapy, diuretics, antidiuretics, uricosuric drugs.

VPT 606 ENDOCRINE AND REPRODUCTIVE PHARMACOLOGY 2+0

Objective

To study the pharmacology of drugs affecting endocrine functions.

Theory

UNIT I: Pharmacology of drugs affecting endocrine functions of pituitary, thyroid, adrenals and pancreas.

UNIT II: Hormonal regulation of calcium and phosphorus homeostasis.

UNIT III: Pharmacology of drugs affecting male reproductive organs, spermatogenesis.

UNIT IV: Pharmacology of drugs affecting female reproductive organs, ovulation, oestrus, conception, gestation and lactation.

UNIT V: Oxytocic and tocolytic drugs.

VPT 607 CHEMOTHERAPY 2+1

Objective

To study the recent advances of chemotherapeutic agents with relevance to

pharmacological and therapeutic aspects.

Theory

UNIT I: General consideration and principles of chemotherapy, classification of

chemotherapeutic agents; development of microbial resistance to antimicrobials, combination therapy.

UNIT II: Systemic and gut acting sulfonamides, diaminopyrimidines, quinolones sulfones, nitrofurans.

UNIT III : Penicillins, cephalosporins, beta-lactam antibiotics.

UNIT IV: Chloramphenicol, tetracyclines, macrolides, polymixins, polypeptides.

UNIT V: Aminoglycosides and other antibiotics.

UNIT VI: Anti-protozoans, anthelmintics, ectoparasiticides.

UNIT VII: Antituberculosis, antifungal, antiviral and antineoplastic drugs.

Practical

General methods for assay of chemotherapeutic agents, antibiotic sensitivity

tests, estimation of sulfonamides, penicillins, oxytetracyclines, trimethoprim and nitrofurans in biological fluids to study their kinetics and bioavailability.

VPT 608 TOXICOLOGY OF XENOBIOTICS 2+1

Objective

To study the poisonings and their antidotal therapy in animals.

Theory

UNIT I: Principles and scope of toxicology, sources of poisoning.

UNIT II: General modes of action of poisons, detoxification, factors affecting toxicity, general principles of diagnosis and treatment of poisonings.

UNIT III: Toxicology of metals, agrochemicals, solvents and vapors, feed additives.

UNIT IV: Toxic effects of radiations and radioactive chemicals, genetic and developmental toxicology; forensic and regulatory aspects of toxicology.

Practical

Extraction, separation and detection of common poisons in toxicological

specimens, study of toxicity and antidotal treatment in animals, designing of

animal toxicity experiments and general toxicity tests.

VPT 609 TOXICOLOGY OF PLANTS AND TOXINS 2+0

Objective

To impart knowledge of toxicity of poisonous plants & natural toxins.

Theory

UNIT I: Classification, identification and chemical constituents of poisonous plants.

Plants containing cyanide, nitrate/nitrite, oxalate, lectins and cardiotoxic glycosides.

UNIT II: Plants producing lathyrism, thiamine deficiency and photosensitization.

UNIT III:Toxicology of mycotoxins: aflatoxins, rubratoxins, ochratoxins, trichothecenes, tremorgens and ergot.

UNIT IV: Animal bites and stings: snake venom, scorpion, spider and insect stings and toad poisoning. Bacterial toxins: botulism.

VPT 610 PHARMACOLOGICAL TECHNIQUES 1+1

Objective

To impart the knowledge of various basic pharmacological techniques and

screening methods of drugs.

Theory

UNIT I: Principles of drug action and bioassay. Dose response curves and their

analysis.

UNIT II: Techniques for setting up isolated and intact preparations.

UNIT III: Organization of screening programme of drugs; multidimensional screening

procedures and gross observational methods.

Practical

Setting up of isolated and intact preparations, recording of BP in dog/rat,

recording of ECG in rat, experiments on drug potentiation, antagonism and

tachyphylaxis. Construction of dose-response plots, calculation of EC, dissociation rate constants, potency ratio, pAx, pDx and pD’ values.Specific tests for evaluation of tranquillizing, hypnotic, analgesic, anticonvulsant, general and local anesthetic, muscle relaxant, antiinflammatory, antipyretic, antiarrhythmic, antihypertensive, antihyperglycemic and anticholesterimic activities. Determination of potency ratio, median effective, toxic or lethal doses. Bioassay techniques.

VPT 611 TECHNIQUES IN TOXICOLOGY 1+1

Objective

To understand the animal toxicity tests and assessment of various toxicants

using specific tests.

Theory

UNIT I: Animal models in toxicological studies.

UNIT II: Animal toxicity tests for acute, sub-acute and chronic toxicity.

UNIT III: Specific toxicity tests for neurotoxicity, immunotoxicity, developmental,

behavioural, reproductive and inhalation toxicity, mutagencity, carcinogenicity.

UNIT IV: Animal toxicological tests for the study of metabolism, synergism and antagonism.

Practical

Tests for acute, sub-acute and chronic toxicity, protocols and various specific toxicity tests. Assay for marker enzymes, analysis of toxicant residues in biological materials.

VPT 612 ETHNOPHARMACOLOGY 2+0

Objective

To impart the knowledge and importance of traditional Indian medicine.

Theory

UNIT I: Historical aspects: Traditional Indian remedies and regional folklore in

disease cure.

UNIT II: Classification, identification and chemical constituents of medicinal plants. Extraction, distillation, evaporation and other processes used in purification and preparation of active constituents from medicinal plants.

UNIT III: Standardization and clinical validation of bioactive molecules from vegetable sources. Therapeutic and adverse effects of potential herbal drugs. Indigenous drugs used as carminatives, antiseptics, antimicrobials, analgesics, and anti-inflammatory agents.

UNIT IV: Alternate systems of medicine in animals.

List of Research Topics of P.G. Theses

Sr.No	Name Of Thesis	Name Of Student	Year	Major Guide
1	Studies Of Record Of Blood Pressure OnNormalDogs By Using Sphygmomanometer	Dr.M.K.Shingategeri	1964
2	Electrophoretic Studies Of Serum Protein In Infectious Canine Hepetitis	Dr. H. V .Jahagirdar	1967
3	Studies On The Absorption ,Acetylation And Excretion Of Common Sulphonamides InBuffaloCalves	Dr. R. D. Sadekar	1970	Dr.M.K. Shingatgeri
4	Pharmacological Studies On Curcuma Longa Linn With Special Reference To Its Anti-Inflammatory Effects In Rats	Dr. .K. R. Wagh	1972	Dr.M.K. Shingatgeri
5	Study Of Some Indigenous Drugs For Their Estrogenic Activity	Dr. S. T. Kalkar	1976	Dr.M.K. Shingatgeri
6	Study On Bioavailability Of Oxytetracycline In Buffloes	Dr .M .I. Qureshi	1976	Dr H V Jahagirdar
7	Toxicological Study Of Intravenous Metronidazole In Laboratory Animals	Dr .S. J. Rajahansa	1979	Dr.M.K. Shingatgeri
8	Study On Propetamphos A New Acaricide With Particular Referance To Its Biologicals Efficacy , Toxicity To Dogs And Ld 50 Determination In Rats	Dr .A .N .Subnis	1980	Dr S Jagadish
9	Disposition Of Ampicillin In Serum And Tissue Fluid InBuffaloCalves	Dr K. Jaykumar	1982	Dr V V Ranade
10	A Preliminary Study On Mercury Residues In Dairy Animal In ThaneKalyan KaluRiver Industrial Belt	Dr D.S . Naoley	1983	Dr H V Jahagirdar
11	Toxicological Investigation Of Sulfadiazine-Trimethoprim Combination In Broilers	Dr. M.R Kulkarni	1983	Dr H V Jahagirdar
12	Studies On The Immunomodullatory Effects Of Levamisole Indomethacin And Metronidazole On Immediate Hypersensitivity In Lab. Animal	Dr R N Naik	1984	Dr S Jagadish
13	Droperidol –A Premedicant In Thiopentone Sodium Induced Anaesthesia In Dogs	Dr G B Kulkarni	1984	Dr H V Jahagirdar
14	A Study On Protective Effect Of Indigenous Formulation Against Induced Hepatotoxicity In Albino Rats	Dr H S Modak	1984	Dr H V Jahagirdar
15	Studies On Effects Of Feeding An Indigenous Drug Formulation To Cattle And Poultry	Dr S G Burte	1986	Dr H V Jahagirdar
16	Influence Of Probenecid On Serum Ampicillin Disposition In Dogs	Dr M P. Bhalerao	1986	Dr V V Ranade
17	Studies On Effects Of Coumaphos And Chlorpromazine Interaction In Cattle	Dr R D Kalkar	1986	Dr S Jagadish
18	Effect Of Gentamicin On Thiopentone Anaesthesia In Dogs	Dr S Madav	1986	Dr S Jagadish
19	Studies On Interaction Between The Anticonvulsant Drugs Phenyton And Phenobarbital In Dogs	Dr A G Telang	1988	Dr S Jagadish
20	Comparitive Studies Of The Effect Of Levamisole Administration Through Different Routes On Immunomodulation And Anthelmentics Activity In Crossbred Animals	Dr L K Sharma	1988	Dr. S Jagadish
21	Therapeutic Evaluation Of Oral And Parenteral Iron Preparations In Experimental Haemorrhagic Anaemia In Crossbred Calves	Dr S S Panchpor	1989	Dr. V V Ranade
22	Pharmacokinetic Studies Of An Injectable Ibuprofen In Dogs And Cattle And Its Safety Assessment To Dogs	Dr S B Raut	1989	Dr. V V Ranade
23	Pharmacokinetic Studies And Safety Assessment Of An Injectable-Aspirin In Calves	Dr M T Raut	1990	Dr. V V Ranade
24	Studies Of Gentamicin Disposition In Blood And Milk Of Lactating Ewes After Parenteral Administration	Dr S K Toke	1990	Dr V V Ranade
25	A Study On Lead Levels In Cattle Located Around The Industrial Area Near Udhva And Kalamdevi Villages In Dist-Thane	Dr A P Pontis	1991	Dr V V Ranade
26	Study Of Estrogenic Activity Of Indigenous Test Preparation (Heatinee)	Dr P K Nemade	1993	Dr V V Ranade
27	Pharmacokinetic Studies And Safety Assessment Of An Injectable-Tiamulin In Sheep And Goats	Dr P C Badole	1993	Dr V V Ranade
28	Study On Efficacy And Safety Of Providone –Iodine In Some Veterinary Clinical Indications	Dr B B Gunjate	1994	Dr. V V Ranade
29	Pharmacokinetic Profile And Safety Assessment Of Pefloxacin Injection In Lactating Cows	Dr R V Patil	1994	Dr. M.M.Gatne
30	Pharmacokinetic And Safety Studies Of Injectable Diclofenac Sodium InBuffaloCalves	Dr R Jairam	1995	Dr V V Ranade
31	Pharmacokinetics Of Enrofloxacin And Its Concentration In Chicken Meat And Eggs	Dr S V Ingale	1995	Dr M M Gatne
32	Hepatoprotective Effect Of Some Herbal And Homoeopathic Drugs In Experimentally Induced Hepatotoxicity In Rats	DR D S JOSHI	1996	Dr M M Gatne
33	Pharmacokinetic Studies And Safety Assessment Of Pefloxacin In Lactating Sheep	Dr R P Chandanshive	1996	Dr V V Ranade
34	Pharmacokinetic Profile And Safety Assessment Of Pefloxacin Injection In Lactating Goats	Dr N M Jare	1996	Dr M M Gatne
35	Pharmacokinetics Of Oral Amoxycillin In Broiler Chickens And Its Comparative Serum Profile After Pulse Dose And Continuous Medication	Dr P K Hendre	1997	Dr M M Gatne
36	Clinical Efficacy And Residue Studies Of Intramammary Infusion Of Enrofloxacin In Mastitic Buffaloes	Dr S C Borkar	1998	Dr M M Gatne
37	Study Of Serum Disposition Of Long-Acting Ampicillin In Cow AndBuffaloCalves	Dr D A Deshpande	1998	Dr V V Ranade
38	Clinical Evaluation And Passage Of Enrofloxacin Across Uterus In Repeat Breeding Buffaloes	Dr A H Pawar	1999	Dr V V Ranade
39	Pharmacokinetic Studies Of Chloramphenicol In Buffaloes	Dr V S Shinde	1999	Dr M M Gatne
40	Disposition Of Paracetamol In Serum And Cerebrospinal Fluid In Buffaloes	Dr S S Pawar	1999	Dr M M Gatne
41	Pharmacokinetic Study Of Amoxycillin And Its Disposition In Cerebrospinal Fluid And Urine InBuffaloCalves After Intravenous Administration	Dr D A Kamble	2000	Dr M M Gatne
42	Pharmacokinetic Studies Of Cefotaxime And Its Disposition In Cerebrospinal Fluid And Urine InBuffaloCalves After Intravenous Administration	Dr P A Patil	2000	Dr M M Gatne
43	Studies On Influence Of Shatavari(Asparagus Racemosus)Feeding On Milk Production In Animals	Dr C M Khdadtare	2000	Dr A P Somkuwar
44	Studies On Disposition Kinetics Of Oxytetracycline InBuffaloCalves By I.M. And I.V. Routes And Its Iteraction With I.V. Calcium	Dr S R Giri	2001	Dr M D Deore
45	Pharmacokinetics Of Ceftrioxone And Its Disposition In Various Body Fluids In Buffalo-Calves	Dr P P Gaikwad	2001	Dr M M Gatne
46	Pharmacokinetic Studies On Diminazene InBuffaloCalves	Dr M M Mehendale	2001	Dr M D Deore
47	Pharmacokinetics Of Ceftriaxone And Its Urinary Excretion In Goats	Dr S R More	2002	Dr M M Gatne
48	Feeicacy Of Combination Of Mannan Oligosaccharide,Organic Acids,Zeolite And Activated Charcoal On Performance And During Induced Alfatoxicosis In Chickens	Dr A M Dafe	2002	Dr M M Gatne
49	Pharmacokinetic Studies On Long Acting Enrofloxacin And Its Comparison With Conventional Enrofloxacin After Single Intramuscular Administration In Cow Calves	Dr C Lalmuanthanga	2002	Dr M D Deore
50	Clinical Efficacy Of Spot On Formulation Of Fipronil In Dogs Infested With Ticks And Fleas And Its In Vitro Efficacy Against Common Dog Tick Rhipicephalus Sanguineus	Dr K M Telang	2003	Dr M M Gatne
51	Pharmacokinetics And Urinary Excretion Of Amikacin In Calves	Dr.S B Khobragade	2003	Dr.M D Deore
52	Pharmacokinetics Of Ceftiofur And Its Urinary Excretion InBuffalo In Calves	Dr B D Ghanshyam	2004	Dr M M Gatne
53	Clinical Evaluation And Toxicity Studies Of Long Acting And Convetional Formulation Of Ivermectin	Dr S S Dadarkar	2004	Dr M D Deore
54	Pharmacokinetics Of Ceftiofur In Chickens	Dr D P Vaijnathrao	2005	Dr M D Deore
55	Isobologram Analysis Of Amoxicillin And Cloxacillin Combination Against Some Bacterial Isolates Of Veterinary Importants	Dr A M Patil	2005	Dr M D Deore
56	Pharmacokinetics And Disposition Of Ceftiofur In Various Body Fluids InBuffalo	Dr P S Bhoir	2005	Dr M M Gatne
57	Isobologram Analysis Ofcombination Of Sulfamethoxazole And Trimethoprim Against Some Bacterial Isolates Of Veterinary Importance	Dr Ramesh	2005	Dr M M Gatne
58	Pharmacokinetics Of Danofloxacin In Buffaloes	Dr S R Malsure	2006	Dr M M Gatne
59	Efficacy Of Combination Of Organic Acids Against Experimentally Induced Gout In Chicken	Dr V D Suryawanshi	2006	Dr M M Gatne
60	Studies On Antiiral Activity Of Mangrove Plant Acanthus Ilicifolius In Poultry	Dr D S Jondhale	2006	Dr M D Deore
61	Pharmacokinetics Of Sparfloxacin In Broiler Chicken	Dr S P Chawade	2007	Dr M D Deore
62	Toxicity And Residue Study Of Florfenicol In Chiken	Dr Elizabeth Kimtei	2008	Dr M M Gatne
63	Pharmacokinetics And Efficacy Of Different Formulations Of Florfenicol In Chicken	Dr N S Adsul	2008	Dr M M Gatne
64	In Vitro Screening Of Qt Ppolongging Drugs For Their Arrthythgenic Potential In Isolated Rabbit Heart	Dr P S Gurav	2009	Dr M M Gatne
65	Neuroprotective Effect Of Peroxisome Proliferator-Activated Receptor –Gamma Agonist And Statin On Eebral Ischemia And Reperfusion Induced Cerebral Injury In Rats	Dr G R Ghangale	2009	Dr M M Gatne
66	Efficacy Of Phyllanthus Niruri Against InducedNewcastleDisease Virusinfection In Chicken	Dr K Anbarasan	2009	Dr M M Gatne
67	Screening Of Qt Prolonging Drugs For Their Arrythmogenic Potential In Anaestetized Rabbit	Dr G H Chaudhari	2009	Dr M M Gatne
68	Studies On Antigenotoxic Effect Of Withania Somnifera In Rats	Dr S P Tamhankar	2009	Dr M M Gatne
69	Studies On Antigenotoxic Effect Of Terminalia Arjuna In Rats	Dr V S Surve	2009	Dr M M Gatne
70	Developmental Immunotoxicity Of Allopurinol In Mice	Dr T R Mahale	2010	Dr M M Gatne
71	Developmental Immunotoxicity Of Imidacloprid In Mice	Dr L B Gawade	2010	Dr M M Gatne
72	Developmental Immunotoxicity Of Fipronil In Mice	Dr A G Somwanshi	2010	Dr M M Gatne

Awards and Recognition

At present the department is recognized by the medical and paramedical institutes in Mumbai for its expertise in the fields of Experimental Pharmacology, Toxicology and Pharmacokinetics.

Faculty of this department has developed enumerable protocols for various studies.

Department has expertise in clinical studies in animals and has undertaken clinical trials for antibiotics, anthelmintics, anti-mastitic preparations, acaricides, coccidiostats, growth promoters etc.

Department has expertise in toxicity studies in laboratory animals which include LD₅₀ studies, subacute toxicity study on insecticides, pesticides, drugs, skin/eye irritation tests, dermal toxicity studies, etc.

This department has successfully organized two national conferences in 1995.
- IInd National convention of Veterinary Pharmacology and Toxicology
- XIII Annual conference of Society of Toxicology.

Department has a cell for providing consultancy services and formulating various pharmacy preparations to the need of pet owners and dairy farmers.

Various techniques have been standardized in the department, viz.

- Large glass assay plate for antibiotic assay.
- Collection of various biological fluids viz. tissue fluid, tears, bile, saliva in large animals.
- Screening of drugs anti-inflammatory, antiulcer, antipyretic, antiobesity, antidiabetic, anticonvulsive, analgesic, antibacterial activity.

List of Paper Published

Sr, No	Title of paper	Authors	Journal, vol, page
1	Influence of probenecid on serum ampicillin disposition in dogs .Indian Vet. J., 67: 506-508	M. M. Gatne, V. V. Ranade and S. Jagadish (1991).	Indian Vet. J., 67: 506-508
2	A modified technique for perfusion of goat mammary gland for studying antibiotic concentration in milk.	V. V. Ranade and M. M. Gatne (1990).	J. Bombay Vet. Coll., 2 (1) : 57-59
3	Serum disposition of long acting and double strength conventional formulation of oxytetracycline in buffaloes.	S. D. Mahashabde, S. Jagadish, M. M. Gatne and V. V. Ranade( 1993) A	Indian Vet. J., 69 (12) : 1147-1148
4	Safety assessment of injectable neomycin in calves.	M. M. Gatne, A. G. Telang, S. K. Toke and V. V. Ranade (1992).	HindustanAntibiotics Bulletin, 34 (3-4) : 108-109
5	Pharmacokinetics of neomycin in calves	M. M. Gatne, S. K. Toke, R. D. Kalkar and V. V. Ranade (1993)	Indian Vet. J., 70 : 422-425
6	Pharmacokinetic studies of an injectable Ibuprofen in cattle.	S. B. Raut, S. Jagadish, M. M. Gatne, M. D. Deore and V. V. Ranade (1993)	Indian Vet. J., 70 (11) : 1008-1010
7	Effect of metoclopramide on plasma disposition of paracetamol in dogs..	M. D. Deore, S. Jagadish, M. M. Gatne, S. B. Raut and V. V. Ranade (1993).	J. Bombay Vet. Coll., 4 (1&2) : 13-16
8	Studies on serum gentamicin disposition after parenteral administration in ewes.	S. K. Toke, M. M. Gatne, P. K. Nemade and V. V. Ranade (1993)	HindustanAntibiotics Bulletin, Aug. Nov., 1993
9	Pharmacokinetics of Tiamulin in calves after single intramuscular administration.	M. M. Gatne, P. C. Badole and V. V. Ranade (1994)	Indian Vet. J., 71 (11): 1148-1149
10	Safety assessment of injectable Ibuprofen in dogs.	S. B. Raut, S. Jagadish, M. D. Deore, M. M. Gatne and V. V. Ranade (1995).	Indian Vet. J., 72:639-641
11	Pharmacokinetics of Tiamulin in sheep after single intramuscular administration.	M. M. Gatne, P. C. Badole and V. V. Ranade (1995).	Indian Vet. J., 72 (3) : 287-289
12	Pharmacokinetics and milk concentration of Pefloxacin injection (PELWIN) in lactating cows.	R. V. Patil, M. M. Gatne, A. P. Somkuwar and V. V. Ranade (1996).	Indian Vet. J., 73 Nov.1996: 1130-1132
13	Disposition of Enrofloxacin in some biological fluids of buffaloes	M.M.Gatne (1999).	Thesis submitted for award of Ph. D. to Konkan Krishi Vidyapeeth, Dapoli, Dist. Ratnagiri.
14	Fluoroquinolones In “ Veterinary Pharmacology and Toxicology,	V.V.Ranade and M.M.Gatne (2001)	ed. B.K.Roy, Kalyani publishers,New Delhi
15	In-vitro erythrocytic partitioning of diminazene in buffaloes J. Bom. Vet. Coll. 9 (1&2),13-14	Mehedndale M.M., GatneM.M. and Deore M.D. (2001)	J. Bom. Vet. Coll. 9 (1&2),13-14
16	Disposition kenetics of Oxytetracycline in buffalo calves.	S.R.Giri, M.D.Deore and M.M.Gatne (2001)	J.Vet. Pharmacol. Toxicol. Vol. 1,30-33.
17	Evaluation of Embliica officinalis for its anti-inflammatory activity in rats	PawarS.D., A.P.Somkuwar, M.D.Deore and M.M.Gatne	.J. Bom. Vet. Coll.10 (1&2), 12-14
18	Evaluation of galactogogue effect of a herbal preparation in nursing rats and buffaloes.	PawarS.D., Somkuwar A.P., Deore M.D. and Gatne M.M. (2003)	J. Bomb. Vet. Coll. 11(1&2), 6-8
19	Safety evaluation of amikacin after its repeated administration for five days in buffalo calves.	Khobragade S.B., Deore M.D. and Gatne M.M. (2003)	.Bomb. Vet. Coll. 11(1&2), 52-53
20	Effect of Awala on carbon tetrachloride induced hepatotoxicity in rats.,	S.D. Pawar, A.P. Somkuwar, M.D.Deore and M.M. Gatne(2003	Toxicology International,10(2):12-23
21	Clinical evaluation of Emblica officinalis for its activity against liver disorders in cattle	Pawar S. D., Somkuwar A.P., Deore M.D. and Gatne M.M. (2004)	. J. Bomb. Vet. Coll.12(1&2): 15-16.
22	Pharmacokinetic studies on long acting and conventional Enrofloxacin in cow calves.	Lalmuanthanga, M.D. Deore, M.M. Gatne and S.B. Khobragade (2005)	Indian Vet. J. 82 : 943-946
23	Toxicity studies of Metoprolol succinate after repeated oral exposure in albino rats	M.D. Deore, S.S. Dadarkar, D.G. Bakre and M. M. Gatne (2005)	Toxicol. Int. 12(2): 101-107
24	Hepatoprotective effect of ‘Livovet’ on mycotoxin induced liver damage in poultry.	M.D. Deore, M.M. Gatne and S.D. Pawar (2005)	J. Vet. Pharmacol. Toxicol. 4(1-2): 10-14
25	Immunotoxicity studies of imidacloprid in rats	M.M.Gatne, Ramesh, P.S. Bhoir, M. D. Deore (2006 )	Toxicology International, 13 (2): 89-92
26	Pharmacokinetics of Tiamulin in goats after single intramuscular administration	P.C..Badole, V.V.Ranade, M.M.Gatne and A.P.Somkuwar (2005)	The Royal Veterinary Journal Of India, Vol.1(1) 55
27	Precliminary evaluation of a polyherbal formulation for its galactogogue properties in primiparous wistar rat.	Dadarkar S.S.,Deore M.D.& Gatne M.M.(2006).	J.BombayVeterinaryCollege,13
28	Comparative evaluation of acute toxicity of ivermectin by two methodsafter single subcutaneous administration in rats.(2007)	Dadarkar S.S.,Deore M.D.& Gatne M.M	Regulatory Toxicology&Pharmacology, INPRESS
29	Development of Budesonide Microparticles Using Spray-Drying Technology for Pulmonary Administration: Design, Characterization, In Vitro Evaluation, and In Vivo Efficacy Study	Sonali R Naikwade, Amrita N Bajaj, Prashant Gurav, Madhumanjiri M Gatne and Pritam Singh Soni	AAPS PharmSciTech (2009)
30	In-vitro red blood cell partitioning of doxycycline	P.V. Deshmukh, P.C. Badgujar, and M.M. Gatne	Indian J Pharmacol. 2009 August; 41(4): 173–175.

Completed Research Projects

Sr. No.	Scheme	Agency	Year
1	Pharmacokinetics of selected drugs in buffaloes	ICAR	1998-2001
2	Establishment of Indigenous drug research Unit	ICAR	1998-2001
3	Acute and subacute toxicity studies of some Bhasmas ( co investigator)	CCRAS	2006-2007
4	Testing efficacy of antidandruff formulation in dogs	CCRAS	2008-2009
5	Outreach program on monitoring of drug residues and environmental pollutants	ICAR	2009-2012

Retired Professors

Dr. M. K. Joshirao

Dr. M. K. Shingatgeri,

Dr. H. V. Jahagirdar,

Dr. S. Jagadish

Dr. V.V. Ranade

Veterinary Pharmacology and Toxicology

UG Syllabus

PG Syllabus

List of Research Topics of P.G. Theses

Awards and Recognition

List of Paper Published

Completed Research Projects

Retired Professors

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